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 HOME > 제품소개 > PUMP >
정밀연동펌프 |
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| ChemTec™ |
| Intelligent Metering System |
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Automated Feed Regulation with Cell Growth Monitor
Programmed Linear or Exponential Feed by Weight or Volume
Real-Time Data Collection and Graphing
Programmable Control of Two 6-Port Rotary Valves
Other Apps Include: Automated pH and Perfusion
Automated Preparative Chromatography
Monitor Remotely; Safe Walk-Away System Operation
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| Bioreactor and Fermenter Feeding |
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The ChemTec™ Metering System includes on-board application software and hardware that automates,
optimizes and documents high precision metering by weight or volume. The ChemTec™ System is an
exclusive software-driven fl uid delivery system that automatically regulates feed-rate based on user
defi ned time schedule or feedback from sensors and detectors (e.g. Cell Growth Monitor). |
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| ChemTec™ Pump Head Options: |
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| 1. Reactor Monitoring / Control: Use of pH and Biomass Monitors |
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Programmable Modes:
The ChemTec™ Smart Metering System provides user-defi nable
bioreactor feeds either by volume or by weight. The “Tandem”
two-channel peristaltic pump head allows simultaneous “feed
and bleed”, capable of maintaining a constant reactor volume.
By connecting to an electronic scale, the ChemTec™ becomes
a self-calibrating metering system. The feed rates are executed
on a user-programmable time schedule. Linear and exponential
feed gradients are readily implemented from the ChemTec™ front
panel. More complex user-programs are prepared and stored in
Note Pad (in your PC) and uploaded to the ChemTec™. |
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Biomass Monitoring Mode:
The ChemTec™ accepts 4-20 mA signals from sensors or detectors.
Turbidity monitors such as those manufactured by Wedgewood
Technology, Mettler-Toledo and others, provide a 4-20mA signal
that is proportional to the reactor biomass. In the “Biomass
Monitoring” mode, the ChemTec™ pump output is directly
proportional to the signal received from the (turbidity) monitor.
In this confi guration, the ChemTec™ automatically provides the
correct amount of nutrient solution to support biomass growth.
Alternatively, a user-defi nable set-point maintains a constant
turbidity level. |
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| 2. Preparative Chromatography: Safe, Unattended Column Loading |
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Summary:
When loading large, preparative chromatography columns, the
loading pump rate must frequently be reduced from its initial
setting, particularly, when solution constituents retained by the
column cause an increase in column fl ow resistance. Thus, when
operating at a constant pump rate, the column inlet pressure
tends to increase over time. Signifi cant operator time and
attention must be paid to monitoring and adjusting the loading
pump rate, in order to avoid excessive pressure build-up and
column compaction. These issues are completely avoided when
using the ChemTec™ with an in-line pressure sensor. |
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Features:
In the “Chrom-Loading” mode, the ChemTec™ provides userdefi
ned pump rates while, simultaneously, monitoring the column
back pressure. Once a safe, pre-set pressure limit has been
exceeded, the ChemTec™ automatically switches from a constant
rate delivery to a constant pressure delivery, thereby avoiding
unsafe pressure build-up and column compaction. The ChemTec™
maintains a pre-set, constant pressure level by modulating the
pump output. The ChemTec™ stops when a pre-set solution
volume has been loaded onto the column. Alternatively, a bubble
detector or level sensor, placed between the process reservoir and
the ChemTec™, provides a pump-stop signal when the process
reservoir has been emptied. The ChemTec™ provides a safe,
hands-off column loading capability. |
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pH Control / Titrations Mode:
The ChemTec™ automates pH control as well as titrations in
larger-volume reactor applications. In the pH control mode, the
ChemTec™ is connected to a pH transmitter with a 4-20mA output.
The ChemTec™ provides user-defi nable pH Set-Point, which the
ChemTec™ will maintain by adding small increments of reagent.
The pH Set-Point can be maintained indefi nitely within 0.10
pH unit, i.e. the smallest selectable pH Bandwidth. For titration
applications, the user-defi nable pH Set-Point represents the
titration endpoint, e.g. pH Set-Point = pH 7.00 for a simple acid/
base neutralization reaction. |
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| 3. Diafiltration: Use of Scale to Maintain Constant Retentate Volume |
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Summary:
For automated diafi ltration (“washing”) of protein solutions,
the ChemTec™ is connected to an electronic scale on which
the retentate reservoir is located. In the “Diafi ltration” mode,
the ChemTec™ is programmed to maintain a constant retentate
weight. The ChemTec™ automatically adds exchange buffer to the
retentate reservoir to make up for the collected permeate. The
ChemTec™ adds exchange buffer until a user-defi ned volume limit
has been attained. The ChemTec™ also provides a Stop/Start
control over the diafi ltration system. |
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Features:
The SciPro has two fi ltration modes; diafi ltration is carried out
by constant pump rate or by constant trans-membrane pressure
(TMP). The SciPro is a self-supervisory bioprocessing system
that offers fi ve (5) user-defi nable alarms. All alarm parameters,
including TMP and pressures P1, P2 and P3 are continuously
monitored and displayed. All pump parameters can be printed out
or sent to your computer for data archiving. |
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| 4. Perfusion: Continuous Protein Harvesting of Mammalian Cell Cultures |
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Summary:
The use of small-scale mammalian cell cultures maximizes the
production of valuable protein and avoids the high capital costs
associated with system scale-up. However, for a continuous
protein harvesting system, components need to be selected that
guaranty a failure-free system operations for days and weeks.
The ChemTec™ meets this performance standard. Problems
of maintaining a constant bioreactor fl uid level are frequently
associated with level probes and sensors that become inoperable
over time. Excessive solution foaming, as well as a general
gumming up of level sensors, are the primary causes for system
failures. These long-term performance issues are completely
avoided when using the ChemTec™ with a scale. |
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Features:
In the “Perfusion” mode, the ChemTec™ (#1) automatically meters
fresh media into the bioreactor in response to the continuous
removal of cell-free permeate by the ACCU perfusion pump. The
ChemTec™ displays and documents the bioreactor weight as well
as the media volume that has been added to the reactor.
A second ChemTec™ (#2) is used as an automated recirculation
pump that also controls the operation of the ACCU harvesting
pump. The ChemTec™ (#2) will stop and alarm as soon as a userdefi
ned pressure limit has been exceeded, simultaneously, the
unit will stop the ACCU perfusion pump. |
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| Automated Solution Handling |
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For example, controlling two (2) rotary valves
simultaneously, the ChemTec™ automates the liquid
handling of lab-scale preparative chromatography.
The pump rates, as well as the port positions of
the two rotary valves, are controlled on a userprogrammable
time schedule. Stored liquid
handling programs can be uploaded or downloaded
from the ChemTec™ using the PC Hyperterminal.
No third-party software is required! |
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| Dimension: Width: 5.75 in (14.6cm); Height: 8.5 in (212.6); Depth: 11in (27.9). |
| Weight: 14 lbs (6.4kg). |
| Enclosure: 16 Ga, aluminum baked epoxy blue. |
| ChemTec™ Pump Head/Motor Options: |
Peristaltic Models available with Tandem 1081 and/or 1082 heads:
Tandem 1081 uses Masterflex peristaltic pump tubing (thin-walled) sizes: #13, 14, 16, 25, 17 & 18.
Tandem 1082 uses Masterflex peristaltic pump tubing (thick-walled) sizes: #15, 24 & 35.
Tandem peristaltic heads can be piggyback to double flow range.
ChemTec™ CP-8, max. 8 RPM, Flow Range with one Tandem head: 0.03 - 24 ml/min.
ChemTec™ CP-120, max. 160 RPM, Flow Range with one Tandem head: 0.5 - 554 ml/min.
ChemTec™ CP-200, max. 600 RPM, Flow Range with one Tandem head: 2 - 2258 ml/min. |
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Piston Models available mounted with different sized piston heads & choice of wetted parts, e.g.
ceramic, 316SS, Kynar, Tefzel. Max pressure 25-100 psi depending on head choice:>
ChemTec™ FM-420, max. 450 RPM, choice of RH piston head, Flow Range: 0.01 - 50 ml/min.
ChemTec™ FM-520, max 3400 RPM, choice of RH piston head, Flow Range: 2 - 370 ml/min.
ChemTec™ FM-200, max. 600 RPM, choice of Q piston head, Flow Range: 5 - 768 ml/min. |
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Magnetic Gear Models available mounted with different sized magnetic gear heads & choice of wetted
parts, e.g. Ryton, Teflon, 316SS. Pulse-less flow. Max. pressure 40-70 psi depending on head choice:
ChemTec™ MP-320, max. 3400 RPM, choice of magnetic gear sized head, Flow Range: 5 - 3,700 ml/min. |
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Pressure Range:
Tandem Head Pump
Maximum pressure output at tandem peristaltic pump head is 45 psi. Has single point recalibration
feature, when used in volume metric mode. No calibration required when scale is hooked up. |
| Pressure Displayed: Pressure displayed with a resolution of 0.1 psi; choice of bar, psi, kpa. |
Pressure Sensors:
Accommodates SciLog™ disposable pressure sensors. The calibrated pressure range is 0-60 psi.
Any point within this range can be re-calibrated using an external pressure reference source. |
| Power: 115/220-240 VAC, 60/50Hz, 75 Watts; double fused: T1AL 250V (CE: IR35A 250VAC) |
Encoder: 100 pulses per motor revolution for 600 RPM motor.
120 pulses per motor revolution for 8 and 160 RPM motors. And 450 RPM and 3400 RPM motors |
ChemTec™ Balance Options:
Balance with capacity of 2,000 grams x 0.01 g and 8,100 g x 0.1 resolution are most popular.
Larger balance capacities up to 300 Kg available. Ask Scilog |
ChemTec™ Software:
Main menu with eleven operational modes including 6 user definable alarms.
Meter by weight or by volume at a constant rate, with linear ramps or with exponential ramps. |
Documentation Software for PC:
SciDoc™ interface software with custom macros for Excel® for data compilation. Sent to you ready to use.
Complete process analysis with graphing of data.
Real-time verification and documentation of process parameters. |
| Use Range: 4° to 40° C, 100% Humidity. |
| Motor: Choice of five (5) motors: 8, 160, 600, 450 and 3400 RPM at 30VDC, 3.8 Amperes, Variable Pump
Speed, optically encoded servo-controlled motors. |
I/O Ports:
1) First serial port labeled “Balance”, Male DB9 connector for hook-up of electronic scale.
2) Second Serial Port labeled "Printer", Female DB9; also used to interface to PC for data storage in an
Excel® file
in your PC.
3) External I/O port, Female DB37 connector; Used for remote On/Off control of
ChemTec™ via footswitch.
4) Pressure Box: Phone plugs for three(3) optional pressure sensors. |
| Data Entry: Membrane keyboard with auditory feedback. |
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